October 27, 1840

Washington University Record, October 27, 1994

Addendum, Vol. 13, October 27 Release

[Addendum to the article DOI: 10.5888/pcd13.160232.].

Database Searching and BLAST Tuesday , October 27 th

The goal of a database search is to find all “high-scoring” local alignments (i.e, local alignments with a score above a given threshold) and to determine the significance of alignments found. A database search can be used to compare a protein or a cDNA sequence with genomic DNA, e.g. to find gene location or identify intron/exon boundaries. Another application is to find homologous protein seq...

Nicolò Paganini (1782-1840).

Dev114181 1840..1849

Homeoproteins of the Engrailed family are involved in the patterning of mesencephalic boundaries through a mechanism classically ascribed to their transcriptional functions. In light of recent reports on the paracrine activity of homeoproteins, including Engrailed, we asked whether Engrailed intercellular transfer was also involved in brain patterning and boundary formation. Using time-controll...